Intracellular trafficking of ceramide by ceramide transfer protein

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Intracellular trafficking of ceramide by ceramide transfer protein

The transport and sorting of lipids are fundamental to membrane biogenesis. In the synthesis of sphingolipids in mammalian cells, ceramide is newly produced at the endoplasmic reticulum (ER), and transported from the ER to the trans Golgi regions, where it is converted to sphingomyelin. Ceramide transfer protein (CERT) mediates the ER-to-Golgi trafficking of ceramide. It has been suggested that...

متن کامل

Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis.

Ceramide kinase (CERK) is a critical mediator of eicosanoid synthesis, and its product, ceramide-1-phosphate (C1P), is required for the production of prostaglandins in response to several inflammatory agonists. In this study, mass spectrometry analysis disclosed that the main forms of C1P in cells were C(16:0) C1P and C(18:0) C1P, suggesting that CERK uses ceramide transported to the trans-Golg...

متن کامل

Identification of intracellular ceramide target proteins by affinity chromatography and TID-ceramide photoaffinity labelling.

Identification of intracellular ceramide target proteins by affinity chromatography and TID-ceramide photoaffinity labelling M. Wickel*, M. Heinrich*, T. Webert', J. Brunnert, M. Kronke* and S. Schutze*2 *Institute of Immunology, Univenity of Kiel, Michaelisstr. 5, 024 I05 Kiel, Germany and +Department of Biochemistty, Swiss Federal Institute of Technology, Zurich (ETHZ), Univenitatsstr. I 6, C...

متن کامل

Lipid Metabolism: Ceramide Transfer Protein Adds a New Dimension

Just as non-lipidologists were becoming reconciled to the complexities of networks of ceramide metabolism and the diverse roles of ceramide in cell regulation and membrane structure, a new study reveals a new layer of regulation of ceramide through the actions of a ceramide binding/transfer protein.

متن کامل

Regulation of secretory transport by protein kinase D–mediated phosphorylation of the ceramide transfer protein

Protein kinase D (PKD) has been identified as a crucial regulator of secretory transport at the trans-Golgi network (TGN). Recruitment and activation of PKD at the TGN is mediated by the lipid diacylglycerol, a pool of which is generated by sphingomyelin synthase from ceramide and phosphatidylcholine. The nonvesicular transfer of ceramide from the endoplasmic reticulum to the Golgi complex is m...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Proceedings of the Japan Academy, Series B

سال: 2010

ISSN: 0386-2208,1349-2896

DOI: 10.2183/pjab.86.426